Recent Publications

Click on a link below to see publications for specific lab.


Bubeck-Wardenburg Lab (faculty bio) (research summary)

Streptolysin O Rapidly Impairs Neutrophil Oxidative Burst and Antibacterial Responses to Group A StreptococcusUchiyama S, Döhrmann S, Timmer AM, Dixit N, Ghochani M, Bhandari T, Timmer JC, Sprague K, Bubeck-Wardenburg J, Simon SI, Nizet V.  Front Immunol. 2015 Nov 16;6:581. doi: 10.3389/fimmu.2015.00581. eCollection 2015.

Synergistic Action of Staphylococcus aureus α-Toxin on Platelets and Myeloid Lineage Cells Contributes to Lethal Sepsis. Powers ME, Becker RE, Sailer A, Turner JR, Bubeck Wardenburg J. Cell Host Microbe. 2015 Jun 10;17(6):775-87. doi: 10.1016/j.chom.2015.05.011.

Host autophagy combating S. aureus: α-toxin will be tolerated. Powers ME, Bubeck Wardenburg J. Cell Host Microbe. 2015 Apr 8;17(4):419-20. doi: 10.1016/j.chom.2015.03.010.

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Crosson Lab (faculty bio) (research summary)

WrpA is an atypical flavodoxin-family protein under regulatory control of the Brucella abortus general stress response system. Herrou J, Czyż DM, Willett JW, Kim HS, Chhor G, Babnigg G, Kim Y, Crosson S. J Bacteriol. 2016 Feb 8. pii: JB.00982-15. [Epub ahead of print]

Brucella abortus Cell Cycle and Infection Are Coordinated. De Bolle X, Crosson S, Matroule JY, Letesson JJ. Trends Microbiol. 2015 Dec;23(12):812-21. doi: 10.1016/j.tim.2015.09.007. Epub 2015 Oct 20. Review.

Identification of the PhoB Regulon and Role of PhoU in the Phosphate Starvation Response of Caulobacter crescentus. Lubin EA, Henry JT, Fiebig A, Crosson S, Laub MT. J Bacteriol. 2015 Oct 19;198(1):187-200. doi: 10.1128/JB.00658-15.

Evolving new protein-protein interaction specificity through promiscuous intermediates. Aakre CD, Herrou J, Phung TN, Perchuk BS, Crosson S, Laub MT. Cell. 2015 Oct 22;163(3):594-606. doi: 10.1016/j.cell.2015.09.055. Epub 2015 Oct 17.

General Stress Signaling in the Alphaproteobacteria. Fiebig A, Herrou J, Willett J, Crosson S. Annu Rev Genet. 2015 Nov 23;49:603-25. doi: 10.1146/annurev-genet-112414-054813. Epub 2015 Oct 5.

Structured and Dynamic Disordered Domains Regulate the Activity of a Multifunctional Anti-σ Factor. Herrou J, Willett JW, Crosson S. MBio. 2015 Jul 28;6(4):e00910. doi: 10.1128/mBio.00910-15.

Structural asymmetry in a conserved signaling system that regulates division, replication, and virulence of an intracellular pathogen. Willett JW, Herrou J, Briegel A, Rotskoff G, Crosson S. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):E3709-18. doi: 10.1073/pnas.1503118112. Epub 2015 Jun 29.

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Gack Lab (faculty bio) (research summary)

A phosphomimetic-based mechanism of dengue virus to antagonize innate immunity. Chan YK, Gack MU. Nat Immunol. 2016 Mar 21. doi: 10.1038/ni.3393. [Epub ahead of print]

Reading the fine print: sequence-specific activation of cGASChiang JJ, Gack MU.  Nat Immunol. 2015 Oct;16(10):1009-10. doi: 10.1038/ni.3274.

Delicate coordination of TRIM21's dual activity in virus neutralization and signaling. Full F, Gack MU. Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9797-8. doi: 10.1073/pnas.1512642112. Epub 2015 Aug 3.

Intracellular detection of viral nucleic acids. Sparrer KM, Gack MU. Curr Opin Microbiol. 2015 Aug;26:1-9. doi: 10.1016/j.mib.2015.03.001. Epub 2015 Mar 18. Review.

Ubiquitination in the antiviral immune response. Davis ME, Gack MU. Virology. 2015 May;479-480:52-65. doi: 10.1016/j.virol.2015.02.033. Epub 2015 Mar 7. Review.

RIG-I-like receptor regulation in virus infection and immunity. Chan YK, Gack MU. Curr Opin Virol. 2015 Jun;12:7-14. doi: 10.1016/j.coviro.2015.01.004. Epub 2015 Jan 30. Review.

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Golovkina Lab (faculty bio) (research summary)

Mammalian Lipopolysaccharide Receptors Incorporated into the Retroviral Envelope Augment Virus Transmission.  Wilks J, Lien E, Jacobson AN, Fischbach MA, Qureshi N, Chervonsky AV, Golovkina TV. Cell Host Microbe. 2015 Oct 14;18(4):456-62. doi: 10.1016/j.chom.2015.09.005.

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Kanabrocki Lab (faculty bio) (research summary)

Hereditary hemochromatosis restores the virulence of plague vaccine strains. Quenee LE, Hermanas TM, Ciletti N, Louvel H, Miller NC, Elli D, Blaylock B, Mitchell A, Schroeder J, Krausz T, Kanabrocki J, Schneewind O. J Infect Dis. 2012 Oct 1;206(7):1050-8. doi: 10.1093/infdis/jis433. Epub 2012 Aug 14.

Public health and biosecurity. Adaptations of avian flu virus are a cause for concernBerns KI, Casadevall A, Cohen ML, Ehrlich SA, Enquist LW, Fitch JP, Franz DR, Fraser-Liggett CM, Grant CM, Imperiale MJ, Kanabrocki J, Keim PS, Lemon SM, Levy SB, Lumpkin JR, Miller JF, Murch R, Nance ME, Osterholm MT, Relman DA, Roth JA, Vidaver AK.  Science. 2012 Feb 10;335(6069):660-1. doi: 10.1126/science.1217994. Epub 2012 Jan 31.

Policy: Adaptations of avian flu virus are a cause for concernBerns KI, Casadevall A, Cohen ML, Ehrlich SA, Enquist LW, Fitch JP, Franz DR, Fraser-Liggett CM, Grant CM, Imperiale MJ, Kanabrocki J, Keim PS, Lemon SM, Levy SB, Lumpkin JR, Miller JF, Murch R, Nance ME, Osterholm MT, Relman DA, Roth JA, Vidaver AK.  Nature. 2012 Jan 31;482(7384):153-4. doi: 10.1038/482153a.

Interactions between biocontainment laboratories and their communities: a successful work in progress. Kanabrocki J. Trends Microbiol. 2011 May;19(5):209-10. doi: 10.1016/j.tim.2011.01.008. Epub 2011 Feb 23.

Guidelines for Handling Pathogenic Microorganisms and Other Potentially Infectious Materials at Biosafety Level 2 (BSL2).  Institutional Biosafety Committee, Office of Biological Safety, University of Chicago. Kanabrocki, J.A., editor. 2011.

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Manicassamy Lab (faculty bio) (research summary)

Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding. Tripathi S, Pohl MO, Zhou Y, Rodriguez-Frandsen A, Wang G, Stein DA, Moulton HM, DeJesus P, Che J, Mulder LC, Yángüez E, Andenmatten D, Pache L, Manicassamy B, Albrecht RA, Gonzalez MG, Nguyen Q, Brass A, Elledge S, White M, Shapira S, Hacohen N, Karlas A, Meyer TF, Shales M, Gatorano A, Johnson JR, Jang G, Johnson T, Verschueren E, Sanders D, Krogan N, Shaw M, König R, Stertz S, García-Sastre A, Chanda SK. Cell Host Microbe. 2015 Dec 9;18(6):723-35. doi: 10.1016/j.chom.2015.11.002.

La Piedad Michoacán Mexico Virus V protein antagonizes type I interferon response by binding STAT2 protein and preventing STATs nuclear translocation. Pisanelli G, Laurent-Rolle M, Manicassamy B, Belicha-Villanueva A, Morrison J, Lozano-Dubernard B, Castro-Peralta F, Iovane G, García-Sastre A. Virus Res. 2016 Feb 2;213:11-22. doi: 10.1016/j.virusres.2015.10.027. Epub 2015 Nov 3.

Corrigendum: Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity. Schoggins JW, MacDuff DA, Imanaka N, Gainey MD, Shrestha B, Eitson JL, Mar KB, Richardson RB, Ratushny AV, Litvak V, Dabelic R, Manicassamy B, Aitchison JD, Aderem A, Elliott RM, García-Sastre A, Racaniello V, Snijder EJ, Yokoyama WM, Diamond MS, Virgin HW, Rice CM. Nature. 2015 Sep 3;525(7567):144. doi: 10.1038/nature14555. Epub 2015 Jul 8. No abstract available.

Canonical wnt signaling in dendritic cells regulates Th1/Th17 responses and suppresses autoimmune neuroinflammation. Suryawanshi A, Manoharan I, Hong Y, Swafford D, Majumdar T, Taketo MM, Manicassamy B, Koni PA, Thangaraju M, Sun Z, Mellor AL, Munn DH, Manicassamy S. J Immunol. 2015 Apr 1;194(7):3295-304. doi: 10.4049/jimmunol.1402691. Epub 2015 Feb 20.

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Missiakas Lab (faculty bio) (research summary)

Pathogenesis of Staphylococcus aureus Bloodstream InfectionsThomer L, Schneewind O, Missiakas D.  Annu Rev Pathol. 2016 Feb 25.

Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing. Thomer L, Emolo C, Thammavongsa V, Kim HK, McAdow ME, Yu W, Kieffer M, Schneewind O, Missiakas D. J Exp Med. 2016 Mar 7;213(3):293-301. doi: 10.1084/jem.20150074. Epub 2016 Feb 15.

SagB Glucosaminidase Is a Determinant of Staphylococcus aureus Glycan Chain Length, Antibiotic Susceptibility, and Protein Secretion. Chan YG, Frankel MB, Missiakas D, Schneewind O. J Bacteriol. 2016 Jan 25;198(7):1123-36. doi: 10.1128/JB.00983-15.

Bacillus anthracis lcp Genes Support Vegetative Growth, Envelope Assembly, and Spore Formation. Liszewski Zilla M, Lunderberg JM, Schneewind O, Missiakas D. J Bacteriol. 2015 Dec;197(23):3731-41. doi: 10.1128/JB.00656-15. Epub 2015 Sep 21.

Bacillus anthracis tagO Is Required for Vegetative Growth and Secondary Cell Wall Polysaccharide Synthesis. Lunderberg JM, Liszewski Zilla M, Missiakas D, Schneewind O. J Bacteriol. 2015 Nov;197(22):3511-20. doi: 10.1128/JB.00494-15. Epub 2015 Aug 31.

Staphylococcal manipulation of host immune responses. Thammavongsa V, Kim HK, Missiakas D, Schneewind O. Nat Rev Microbiol. 2015 Sep;13(9):529-43. doi: 10.1038/nrmicro3521. Review.

Bacillus anthracis SlaQ Promotes S-Layer Protein Assembly. Nguyen-Mau SM, Oh SY, Schneewind DI, Missiakas D, Schneewind O. J Bacteriol. 2015 Oct;197(19):3216-27. doi: 10.1128/JB.00492-15. Epub 2015 Jul 27.

EsxB, a secreted protein from Bacillus anthracis forms two distinct helical bundles. Fan Y, Tan K, Chhor G, Butler EK, Jedrzejczak RP, Missiakas D, Joachimiak A. Protein Sci. 2015 Sep;24(9):1389-400. doi: 10.1002/pro.2715. Epub 2015 Jul 3.

Glutamate Racemase Mutants of Bacillus anthracis. Oh SY, Richter SG, Missiakas DM, Schneewind O.  J Bacteriol. 2015 Jun;197(11):1854-61. doi: 10.1128/JB.00070-15. Epub 2015 Mar 16.

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Randall Lab (faculty bio) (research summary)

Positive-strand RNA viruses stimulate host phosphatidylcholine synthesis at viral replication sites. Zhang J, Zhang Z, Chukkapalli V, Nchoutmboube JA, Li J, Randall G, Belov GA, Wang X. Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):E1064-73. doi: 10.1073/pnas.1519730113. Epub 2016 Feb 8.

Flunarizine prevents hepatitis C virus membrane fusion in a genotype-dependent manner by targeting the potential fusion peptide within E1Perin PM, Haid S, Brown RJ, Doerrbecker J, Schulze K, Zeilinger C, von Schaewen M, Heller B, Vercauteren K, Luxenburger E, Baktash YM, Vondran FW, Speerstra S, Awadh A, Mukhtarov F, Schang LM, Kirschning A, Müller R, Guzman CA, Kaderali L, Randall G, Meuleman P, Ploss A, Pietschmann T.  Hepatology. 2016 Jan;63(1):49-62. doi: 10.1002/hep.28111. Epub 2015 Oct 9.

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Roizman Lab (faculty bio) (research summary)

miR-H28 and miR-H29 expressed late in productive infection are exported and restrict HSV-1 replication and spread in recipient cells. Han Z, Liu X, Chen X, Zhou X, Du T, Roizman B, Zhou G. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):E894-901. doi: 10.1073/pnas.1525674113. Epub 2016 Feb 1.

Role of activating transcription factor 3 in the synthesis of latency-associated transcript and maintenance of herpes simplex virus 1 in latent state in ganglia. Shu M, Du T, Zhou G, Roizman B. Proc Natl Acad Sci U S A. 2015 Sep 29;112(39):E5420-6. doi: 10.1073/pnas.1515369112. Epub 2015 Aug 24.

The 3 facets of regulation of herpes simplex virus gene expression: A critical inquiry. Roizman B, Zhou G. Virology. 2015 May;479-480:562-7. doi: 10.1016/j.virol.2015.02.036. Epub 2015 Mar 11. Review.

Tristetraprolin Recruits the Herpes Simplex Virion Host Shutoff RNase to AU-Rich Elements in Stress Response mRNAs To Enable Their Cleavage. Shu M, Taddeo B, Roizman B. J Virol. 2015 May;89(10):5643-50. doi: 10.1128/JVI.00091-15. Epub 2015 Mar 11.

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Schneewind Lab (faculty bio) (research summary)

Pathogenesis of Staphylococcus aureus Bloodstream Infections. Thomer L, Schneewind O, Missiakas D. Annu Rev Pathol. 2016 Feb 25. [Epub ahead of print]

Antibodies against a secreted product of Staphylococcus aureus trigger phagocytic killing. Thomer L, Emolo C, Thammavongsa V, Kim HK, McAdow ME, Yu W, Kieffer M, Schneewind O, Missiakas D. J Exp Med. 2016 Mar 7;213(3):293-301. doi: 10.1084/jem.20150074. Epub 2016 Feb 15.

SagB Glucosaminidase Is a Determinant of Staphylococcus aureus Glycan Chain Length, Antibiotic Susceptibility, and Protein Secretion. Chan YG, Frankel MB, Missiakas D, Schneewind O. J Bacteriol. 2016 Jan 25;198(7):1123-36. doi: 10.1128/JB.00983-15.

Bacillus anthracis lcp Genes Support Vegetative Growth, Envelope Assembly, and Spore Formation. Liszewski Zilla M, Lunderberg JM, Schneewind O, Missiakas D. J Bacteriol. 2015 Dec;197(23):3731-41. doi: 10.1128/JB.00656-15. Epub 2015 Sep 21.

Bacillus anthracis tagO Is Required for Vegetative Growth and Secondary Cell Wall Polysaccharide Synthesis. Lunderberg JM, Liszewski Zilla M, Missiakas D, Schneewind O. J Bacteriol. 2015 Nov;197(22):3511-20. doi: 10.1128/JB.00494-15. Epub 2015 Aug 31.

Staphylococcal manipulation of host immune responses. Thammavongsa V, Kim HK, Missiakas D, Schneewind O. Nat Rev Microbiol. 2015 Sep;13(9):529-43. doi: 10.1038/nrmicro3521. Review.

Bacillus anthracis SlaQ Promotes S-Layer Protein Assembly. Nguyen-Mau SM, Oh SY, Schneewind DI, Missiakas D, Schneewind O. J Bacteriol. 2015 Oct;197(19):3216-27. doi: 10.1128/JB.00492-15. Epub 2015 Jul 27.

Glutamate Racemase Mutants of Bacillus anthracis. Oh SY, Richter SG, Missiakas DM, Schneewind O. J Bacteriol. 2015 Jun;197(11):1854-61. doi: 10.1128/JB.00070-15. Epub 2015 Mar 16.

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Shuman Lab (faculty bio) (research summary)

Genomic analysis of 38 Legionella species identifies large and diverse effector repertoires. Burstein D, Amaro F, Zusman T, Lifshitz Z, Cohen O, Gilbert JA, Pupko T, Shuman HA, Segal G. Nat Genet. 2016 Feb;48(2):167-75. doi: 10.1038/ng.3481. Epub 2016 Jan 11.

Joint Transcriptional Control of Virulence and Resistance to Antibiotic and Environmental Stress in Acinetobacter baumannii. Gebhardt MJ, Gallagher LA, Jacobson RK, Usacheva EA, Peterson LR, Zurawski DV, Shuman HA. MBio. 2015 Nov 10;6(6):e01660-15. doi: 10.1128/mBio.01660-15.

Diverse protist grazers select for virulence-related traits in Legionella. Amaro F, Wang W, Gilbert JA, Anderson OR, Shuman HA. ISME J. 2015 Jul;9(7):1607-18. doi: 10.1038/ismej.2014.248. Epub 2015 Jan 9.

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