Recent Publications

Click on a link below to see publications for specific lab.

Bubeck-Wardenburg Lab (faculty bio) (research summary)

Inoshima I, Inoshima N, Wilke GA, Powers ME, Frank KM, Wang Y, Bubeck Wardenburg J. A Staphylococcus aureus Pore-Forming Toxin Subverts the Activity of ADAM10 to Cause Lethal Infection. Nature Medicine. 2011 Oct; 17(10):1310-1314.

Powers, M., Kim, H. K., Wang, Y., and Bubeck Wardenburg, J.  ADAM10 mediates vascular injury induced by Staphylococcus aureus a-hemolysin.  J. Infect Dis. 2012, April 2; Epub ahead of print.

Wilke GA, Bubeck Wardenburg J. Role of a disintegrin and metalloprotease 10 in Staphylococcus aureus alpha-hemolysin-mediated cellular injury. Proc Natl Acad Sci U S A. 2010 Jul 27;107(30):13473-8. Full text.

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Gack Lab (faculty bio) (research summary)

Gack, M.U., Shin, Y.C., Joo, C.H., Urano, T., Liang, C., Sun, L., Takeuchi, O., Akira, S., Chen, Z., Inoue, S., and Jung, J.U. (2007). TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature 446, 916-920.

Gack, M.U., Kirchhofer, A., Shin, Y.C., Inn, K., Liang, C., Cui, S., Myong, S., Ha, T.K., Hopfner, K.P., and Jung, J.U. (2008). Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction. Proc. Natl. Acad. Sci. U.S.A. 105(43):16743-8.

Gack, M.U.*, Albrecht, R.A.*, Urano, T., Inn, K., Huang, I.C., Carnero, E., Farzan, M., Inoue, S., Jung, J.U. and Garcia-Sastre, A. (2009). Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I. Cell Host Microbe 5:439-449.

Rajsbaum, R., Albrecht, R.A., Maharaj, N.P., Wang, M., Versteeg, G.A., Nistal-Villán, E., García-Sastre, A., and Gack, M.U. (2012). Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein. PLoS Pathogens 2012 Nov;8(11):e1003059.

Wies, E. *, Wang, M.K. *, Maharaj, N.P., Chen, K., Zhou, S., Finberg, R. W., and Gack, M.U. (2013). Dephosphorylation of the RNA sensors RIG-I and MDA5 by the phosphatase PP1 is essential for innate immune signaling. Immunity 2013 Mar 21;38(3):437-49.

Pauli, E.-K., Chan Y.K., Davis, M.E., Gableske, S., Wang, M.K., Feister, F.F., and Gack, M.U. (2014). The Ubiquitin-Specific Protease USP15 Promotes RIG-I-Mediated Antiviral Signaling by Deubiquitylating TRIM25. Science Signaling 7, ra3 (2014).

Davis, M.E., Wang, M.K., Rennick, L.J., Full, F., Gableske, S., Mesman, A. W., Gringhuis, S. I.,  Geijtenbeek, T.B.H., Duprex, W.P., and Gack, M.U. (2014). Antagonism of the Phosphatase PP1 by the measles virus V protein is required for innate immune escape of MDA5. Cell Host Microbe 2014 Jul 9;16(1):19-30.

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Golovkina Lab (faculty bio) (research summary)

Kane M, Case LK, Kopaskie K, Kozlova A, MacDearmid C, Chervonsky AV, Golovkina TV. Successful transmission of a retrovirus depends on the commensal microbiota. Science. 2011 Oct 14;334(6053):245-9. Full text.

Kane M, Case LK, Wang C, Yurkovetskiy L, Dikiy S, Golovkina TV. Innate immune sensing of retroviral infection via Toll-like receptor 7 occurs upon viral entry. Immunity. 2011 Jul 22;35(1):135-45. Epub 2011 Jun 30. Full text.

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Kanabrocki Lab (faculty bio) (research summary)

Kanabrocki J. Interactions between biocontainment laboratories and their communities: a successful work in progress. Trends Microbiol. 2011 May; 19(5) 209-10. Full text.

Institutional Biosafety Committee, Office of Biological Safety, University of Chicago. Kanabrocki, J.A., editor. 2011. Guidelines for Handling Pathogenic Microorganisms and Other Potentially Infectious Materials at Biosafety Level 2 (BSL2).

Berns KI, Casadevall A, Cohen ML, Ehrlich SA, Enquist LW, Fitch JP, Franz DR, Fraser-Liggett CM, Grant CM, Imperiale MJ, Kanabrocki J, Keim PS, Lemon SM, Levy SB, Lumpkin JR, Miller JF, Murch R, Nance ME, Osterholm MT, Relman DA, Roth JA, Vivider AK. 2012. Public health and biosecurity.  Adaptations of avian flu virus are a cause for concern. Science. 2012 Feb 10;335(6069):660-1. Epub 2012 Jan 31.  Full text

Berns KI, Casadevall A, Cohen ML, Ehrlich SA, Enquist LW, Fitch JP, Franz DR, Fraser-Liggett CM, Grant CM, Imperiale MJ, Kanabrocki J, Keim PS, Lemon SM, Levy SB,Lumpkin JR, Miller JF, Murch R, Nance ME, Osterholm MT, Relman DA, Roth JA,Vidaver AK. 2012. Policy: Adaptations of avian flu virus are a cause for concern. Nature. 2012 Jan 31;482(7384):153-4. doi: 10.1038/482153a.  Full text

Quenee LE, Hermanas TM, Ciletti N, Louvel H, Miller, NC, Elli D, Blaylock B, Mitchell A, Schroeder J, Krausz T, Kanabrocki J and Schneewind O. 2012 Heriditary Hemochromatosis Restores the Virulence of Plague Vaccine Strains. Journal of Infectious Diseases. 2012 Oct. 1; 206(7):1050-8.  Full text

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Manicassamy Lab (faculty bio) (research summary)

Manicassamy B, Manicassamy S, Belicha-Villanueva A, Pisanelli G, Pulendran B and García-Sastre. Analysis of in vivo dynamics of influenza virus infection in mice using a GFP reporter virus. Proc Natl Acad Sci USA. 2010; 107(25):11531-6. Full Text

Manicassamy B*, Medina-Silva R*, Hai R*, Tsibane T, Stertz S, Nistal-Villán  E,  Palese P, Basler CF and Garcia-Sastre A. Protection of mice against lethal challenge with 2009 H1N1 influenza A virus by 1918-like and classical swineH1N1 based vaccines. PLoS Pathog. 2010 Jan 29;6(1):e1000745. Full Text

Medina RA*, Manicassamy B*, Stertz S*, Seibert CW, Hai R, Belshe RB, Frey SE, Basler CF, Palese P, and García-Sastre A. Pandemic 2009 H1N1 vaccine protects against 1918 Spanish influenza virus. Nature Commun. 2010 Jun 15;1:28. doi: 10.1038/ ncomms1026. Full Text

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Missiakas Lab (faculty bio) (research summary)


Liszewski Zilla M, Chan YG, Lunderberg JM, Schneewind O, Missiakas D. LytR-CpsA-Psr enzymes as determinants of Bacillus anthracis secondary cell wall polysaccharide assembly. J Bacteriol. 2014 Nov 10. pii: JB.02364-14. [Epub ahead of print] Full text

Garufi G, Hendrickx AP, Beeri K, Kern JW, Sharma A, Richter SG, Schneewind O, Missiakas D. Synthesis of lipoteichoic acids in Bacillus anthracis. J Bacteriol. 2012 Aug;194(16):4312-21. doi: 10.1128/JB.00626-12. Epub 2012 Jun 8.  Full text

Kern VJ, Kern JW, Theriot JA, Schneewind O, Missiakas D.  Surface-layer (S-layer) proteins sap and EA1 govern the binding of the S-layer-associated protein BslO at the cell septa of Bacillus anthracis. J Bacteriol. 2012 Aug;194(15):3833-40. doi: 10.1128/JB.00402-12. Epub 2012 May 18  Full text

Anderson VJ, Kern JW, McCool JW, Schneewind O, Missiakas D.  The SLH-domain protein BslO is a determinant of Bacillus anthracis chain length. Mol Microbiol. 2011 Jul;81(1):192-205. doi:10.1111/j.1365-2958.2011.07688.x. Epub 2011 May 17.  Full text


Rauch S, Gough P, Kim HK, Schneewind O, Missiakas D.  Vaccine protection of leukopenic mice against Staphylococcus aureus bloodstream infection. Infect Immun. 2014 Nov;82(11):4889-98. doi: 10.1128/IAI.02328-14. Epub 2014 Sep 2.  Full text

Chan YG, Kim HK, Schneewind O, Missiakas D.  The capsular polysaccharide of Staphylococcus aureus is attached to peptidoglycan by the LytR-CpsA-Psr (LCP) family of enzymes. J Biol Chem. 2014 May 30;289(22):15680-90. doi: 10.1074/jbc.M114.567669. Epub 2014 Apr 21  Full text

Thomer L, Becker S, Emolo C, Quach A, Kim HK, Rauch S, Anderson M, Leblanc JF, Schneewind O, Faull KF, Missiakas D. N-acetylglucosaminylation of serine-aspartate repeat proteins promotes Staphylococcus aureus bloodstream infection. J Biol Chem. 2014 Feb 7;289(6):3478-86. doi: 10.1074/jbc.M113.532655. Epub 2013 Dec 16  Full text

Becker S, Frankel MB, Schneewind O, Missiakas D. Release of protein A from the cell wall of Staphylococcus aureus. Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1574-9. doi: 10.1073/pnas.1317181111. Epub 2014 Jan 13.  Full text

Anderson M, Aly KA, Chen YH, Missiakas D.  Secretion of atypical protein substrates by the ESAT-6 secretion system of Staphylococcus aureus.  Mol Microbiol. 2013 Nov;90(4):734-43. doi: 10.1111/mmi.12395. Epub 2013 Oct 4.  Full text

Chan YG, Frankel MB, Dengler V, Schneewind O, Missiakas D.  Staphylococcus aureus mutants lacking the LytR-CpsA-Psr family of enzymes release cell wall teichoic acids into the extracellular medium.  J Bacteriol. 2013 Oct;195(20):4650-9. doi: 10.1128/JB.00544-13. Epub 2013 Aug 9.  Full text

Thomer L, Schneewind O, Missiakas D.  Multiple ligands of von Willebrand factor-binding protein (vWbp) promote Staphylococcus aureus clot formation in human plasma.  J Biol Chem. 2013 Sep 27;288(39):28283-92. doi: 10.1074/jbc.M113.493122. Epub 2013 Aug 19.  Full text

Richter SG, Elli D, Kim HK, Hendrickx AP, Sorg JA, Schneewind O, Missiakas D. Small molecule inhibitor of lipoteichoic acid synthesis is an antibiotic for Gram-positive bacteria. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3531-6. doi: 10.1073/pnas.1217337110. Epub 2013 Feb 11.  Full text

McAdow M, DeDent AC, Emolo C, Cheng AG, Kreiswirth BN, Missiakas DM, Schneewind O. Coagulases as determinants of protective immune responses against Staphylococcus aureus. Infect Immun. 2012 Oct;80(10):3389-98. doi: 10.1128/IAI.00562-12. Epub 2012 Jul 23.  Full text

Chen YH, Anderson M, Hendrickx AP, Missiakas D. Characterization of EssB, a protein required for secretion of ESAT-6 like proteins in Staphylococcus aureus.  BMC Microbiol. 2012 Sep 25;12:219. doi: 10.1186/1471-2180-12-219.  Full text

Kim HK, Kim HY, Schneewind O, Missiakas D.  Identifying protective antigens of Staphylococcus aureus, a pathogen that suppresses host immune responses.  FASEB J. 2011 Oct;25(10):3605-12. doi: 10.1096/fj.11-187963. Epub 2011 Jul 13.  Full text

McAdow M, Kim HK, Dedent AC, Hendrickx AP, Schneewind O, Missiakas DM. Preventing Staphylococcus aureus sepsis through the inhibition of its agglutination in blood.  PLoS Pathog. 2011 Oct;7(10):e1002307. doi: 10.1371/journal.ppat.1002307. Epub 2011 Oct 20.  Full text

Anderson M, Chen YH, Butler EK, Missiakas DM.  EsaD, a secretion factor for the Ess pathway in Staphylococcus aureus.  Bacteriol. 2011 Apr;193(7):1583-9. doi: 10.1128/JB.01096-10. Epub 2011 Jan 28.  Full text

Cheng AG, McAdow M, Kim HK, Bae T, Missiakas DM, Schneewind O. Contribution of coagulases towards Staphylococcus aureus disease and protective immunity.  PLoS Pathog. 2010 Aug 5;6(8):e1001036. doi: 10.1371/journal.ppat.1001036.  Full text


Schneewind O, Missiakas D.  Sec-secretion and sortase-mediated anchoring of proteins in Gram-positive bacteria.  Biochim Biophys Acta. 2014 Aug;1843(8):1687-97. doi: 10.1016/j.bbamcr.2013.11.009. Epub 2013 Nov 22. Review.  Full text

Kim HK, Missiakas D, Schneewind O.  Mouse models for infectious diseases caused by Staphylococcus aureus.  J Immunol Methods. 2014 Aug;410:88-99. doi: 10.1016/j.jim.2014.04.007. Epub 2014 Apr 24. Review.  Full text

Schneewind O, Missiakas D.  Lipoteichoic acids, phosphate-containing polymers in the envelope of gram-positive bacteria.  J Bacteriol. 2014 Mar;196(6):1133-42. doi: 10.1128/JB.01155-13. Epub 2014 Jan 10. Review.  Full text

Schneewind O, Missiakas D. Genetic manipulation of Staphylococcus aureus.  Curr Protoc Microbiol. 2014 Feb 6;32:Unit 9C.3.. doi: 10.1002/9780471729259.mc09c03s32.  Full text

Kim HK, Thammavongsa V, Schneewind O, Missiakas D.  Recurrent infections and immune evasion strategies of Staphylococcus aureus.  Curr Opin Microbiol. 2012 Feb;15(1):92-9. doi: 10.1016/j.mib.2011.10.012. Epub 2011 Nov 14. Review.  Full text

Cheng AG, DeDent AC, Schneewind O, Missiakas D.  A play in four acts: Staphylococcus aureus abscess formation.  Trends Microbiol. 2011 May;19(5):225-32. doi: 10.1016/j.tim.2011.01.007. Epub 2011 Feb 25. Review.  Full text

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Randall Lab (faculty bio) (research summary)

Heaton, N.S., R. Perera, K.L. Berger, S. Khadka, D.J. LaCount, R.J. Kuhn and G. Randall. 2010. Dengue virus nonstructural protein 3 redistributes fatty acid synthase to sites of viral replication and increases cellular fatty acid synthesis. Proc. Natl. Acad. Sci. USA. 107:17345-50.  Full text.

Heaton, N.S. and G. Randall. 2010. Dengue virus induced autophagy regulates lipid metabolism. Cell Host and Microbe. 8:422-32.  Full text.

Berger, K.L., S.M. Kelly, T.X. Jordan, M.A. Tartell and G. Randall. 2011. Hepatitis C virus stimulates the phosphatidylinositol 4-kinase III alpha-dependent phosphatidylinositol 4-phosphate production that is essential for its replication. J. Virol. 85(17):8870-83.  Full text.

Coller, K.E., N.S. Heaton, K.L. Berger, J.D. Cooper, J. Saunders, and G. Randall. 2012. Molecular determinants and dynamics of hepatitis C virus secretion. PLoS Pathogens. 8(1):e1002466. Epub 2012 Jan 5.  Full text.

Oakland, T.E., K.J. Haselton and G. Randall. 2013. EWSR1 binds the hepatitis C virus cis-acting replication element and is required for efficient replication.  J. Virol. 87(12):6625-34.  Full text.

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Roizman Lab (faculty bio) (research summary)

Du, T., Zhou G., and Roizman, B.  HSV-1 gene expression from reactivated ganglia is disordered and concurrent with suppression of latency associated transcript and miRNAS.  Proc. Nat. Acad. Sci. (USA) 108: 18820-18824 2011.  Full text

Zhou, G., Du, T., Roizman B.  The role of CoREST/RET repressor complex in herpes simplex virus 1 productive infection and latency.  Viruses, 5:1208-1218; doi:10.3390/v5051208, 2013 PMID: 23628827.  Full text

Du, T., Zhou, G. and Roizman, B.  Modulation of reactivation of latent herpes simplex virus 1 in ganglionic organ cultures by p300/CBP and STAT3.  Proc.  Natl. Acad. Sci. (U S A). E2621, 2013 [Epub ahead of print June 20, 2013] PMID: 23788661. Full text

Kalamvoki, M  and Roizman, B..  HSV-1 degrades, stabilizes, requires, or is stung by STING depending on ICP0, the US3 protein kinase and cell derivation. Proc. Nat. Acad. Sci.  (USA) 2014; 111:E611-E617, February 3, 2014 (10.1073/pnas.1323414111). Originally published at on Jan 21 2014  Full text

Kalamvoki M Du T. and Roizman B.  Cells infected with herpes simplex virus 1 export to uninfected cells exospores containing STING, viral mRNAs, and micro RNAs. Proc. Nat. Acad. of Sci.  USA. 111:E4991-E4996, November 18, 2014 (10.1073/pnas.1419338111).  Full text

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Schneewind Lab (faculty bio) (research summary)

McAdow M, Kim HK, Dedent AC, Hendrickx AP, Schneewind O, Missiakas DM. Preventing Staphylococcus aureus Sepsis through the Inhibition of Its Agglutination in Blood. PLoS Pathog. 2011 Oct;7(10):e1002307. Full text.

Frankel MB, Hendrickx AP, Missiakas DM, Schneewind O. LytN, a murein hydrolase in the cross-wall compartment of Staphylococcus aureus, is involved in proper bacterial growth and envelope assembly. J Biol Chem. 2011 Sep 16;286(37):32593-605. Full text.

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Shuman Lab (faculty bio) (research summary)

Amaro F, Wang W, Gilbert JA, Anderson, OR, Shuman HA. Diverse protist grazers select for virulence-related traits in Legionella. ISME J 2015 In the Press. doi:10.1038/ismej.2014.248

Jacobs AC, Thompson MG, Gebhardt M, Corey BW, Yildirim S, Shuman HA, Zurawski  DV. Genetic Manipulation of Acinetobacter baumannii. Curr Protoc Microbiol. 2014  Nov 3;35:6G.2.1-6G.2.11. doi: 10.1002/9780471729259.mc06g02s35. PubMed PMID: 25367274.  Full text

Czyż DM, Potluri LP, Jain-Gupta N, Riley SP, Martinez JJ, Steck TL, Crosson S, Shuman HA, Gabay JE. Host-directed antimicrobial drugs with broad-spectrum efficacy against intracellular bacterial pathogens. MBio. 2014 Jul 29;5(4):e01534-14. doi: 10.1128/mBio.01534-14. PubMed PMID: 25073644; PubMed Central PMCID: PMC4128363.  Full text

Lifshitz Z, Burstein D, Peeri M, Zusman T, Schwartz K, Shuman HA, Pupko T, Segal G. Computational modeling and experimental validation of the Legionella and Coxiella virulence-related type-IVB secretion signal. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E707-15. doi: 10.1073/pnas.1215278110. Epub 2013 Feb 4. PubMed PMID: 23382224; PubMed Central PMCID: PMC3581968.  Full text

Franco IS, Shohdy N, Shuman HA. The Legionella pneumophila effector VipA is an actin nucleator that alters host cell organelle trafficking. PLoS Pathog. 2012 Feb;8(2):e1002546. doi: 10.1371/journal.ppat.1002546. Epub 2012 Feb 23. PubMed PMID: 22383880; PubMed Central PMCID: PMC3285593.  Full text

Amaro F, Gilbert JA, Owens S, Trimble W, Shuman HA. Whole-genome sequence of the human pathogen Legionella pneumophila serogroup 12 strain 570-CO-H. J Bacteriol. 2012 Mar;194(6):1613-4. doi: 10.1128/JB.06626-11. PubMed PMID: 22374950; PubMed Central PMCID: PMC3294838.  Full text

Faucher SP, Mueller CA, Shuman HA. Legionella pneumophila Transcriptome during Intracellular Multiplication in Human Macrophages. Front Microbiol. 2011 Apr 4;2:60. doi: 10.3389/fmicb.2011.00060. eCollection 2011. PubMed PMID: 21747786; PubMed Central PMCID: PMC3128937.  Full text

Levi A, Folcher M, Jenal U, Shuman HA. Cyclic diguanylate signaling proteins control intracellular growth of Legionella pneumophila. MBio. 2011 Jan 11;2(1):e00316-10. doi: 10.1128/mBio.00316-10. PubMed PMID: 21249170; PubMed Central PMCID: PMC3023162.  Full text

Anderson OR, Wang W, Faucher SP, Bi K, Shuman HA. A new heterolobosean amoeba  Solumitrus palustris n. g., n. sp. isolated from freshwater marsh soil. J Eukaryot Microbiol. 2011 Jan-Feb;58(1):60-7. doi: 10.1111/j.1550-7408.2010.00520.x. PubMed PMID: 21182560.  Full text

Hovel-Miner G, Faucher SP, Charpentier X, Shuman HA. ArgR-regulated genes are derepressed in the Legionella-containing vacuole. J Bacteriol. 2010 Sep;192(17):4504-16. doi: 10.1128/JB.00465-10. Epub 2010 Jul 9. PubMed PMID: 20622069; PubMed Central PMCID: PMC2937375.  Full text

Faucher SP, Friedlander G, Livny J, Margalit H, Shuman HA. Legionella pneumophila 6S RNA optimizes intracellular multiplication. Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7533-8. doi: 10.1073/pnas.0911764107. Epub 2010 Apr 5. PubMed PMID: 20368425; PubMed Central PMCID: PMC2867745.  Full text

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