Glenn C. Randall, PhD

Our laboratory investigates the roles of virus-host interactions in replication and pathogenesis. We study RNA viruses, including hepatitis C virus, dengue virus, Zika virus, and noroviruses. These are medically important viruses, causing cirrhosis/liver cancer, hemorrhagic fever, birth defects, and severe GI disease, respectively.



We have identified ~100 host cofactors of viral replication. We now study the importance of these cellular genes in diverse steps of the viral life cycle, including entry, the regulation of viral protein translation and RNA replication, modulation of cellular lipid metabolism, the establishment of viral replication complexes, the secretion of infectious virus, and control of infection by the innate immune system.

Rockefeller University
New York, NY
Postdoc - Virology
2005

The University of Chicago
Chicago, IL
Ph.D. - Virology
1999

University of Illinois
Urbana, IL
B.S. - Microbiology
1993

Soluble Angiotensin-Converting Enzyme 2 Protein Improves Survival and Lowers Viral Titers in Lethal Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection with the Delta Variant.
Soluble Angiotensin-Converting Enzyme 2 Protein Improves Survival and Lowers Viral Titers in Lethal Mouse Model of Severe Acute Respiratory Syndrome Coronavirus Type 2 Infection with the Delta Variant. Cells. 2024 Jan 23; 13(3).
PMID: 38334597

Roles of epidermal growth factor receptor, claudin-1 and occludin in multi-step entry of hepatitis C virus into polarized hepatoma spheroids.
Roles of epidermal growth factor receptor, claudin-1 and occludin in multi-step entry of hepatitis C virus into polarized hepatoma spheroids. PLoS Pathog. 2023 Dec; 19(12):e1011887.
PMID: 38157366

CAPRIN1 Is Required for Control of Viral Replication Complexes by Interferon Gamma.
CAPRIN1 Is Required for Control of Viral Replication Complexes by Interferon Gamma. mBio. 2023 06 27; 14(3):e0017223.
PMID: 37052473

Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection.
Intranasal soluble ACE2 improves survival and prevents brain SARS-CoV-2 infection. Life Sci Alliance. 2023 07; 6(7).
PMID: 37041017

Superiority of intranasal over systemic administration of bioengineered soluble ACE2 for survival and brain protection against SARS-CoV-2 infection.
Superiority of intranasal over systemic administration of bioengineered soluble ACE2 for survival and brain protection against SARS-CoV-2 infection. bioRxiv. 2022 Dec 06.
PMID: 36523403

Transcriptional Inhibition of MicroRNA miR-122 by Small Molecules Reduces Hepatitis C Virus Replication in Liver Cells.
Transcriptional Inhibition of MicroRNA miR-122 by Small Molecules Reduces Hepatitis C Virus Replication in Liver Cells. J Med Chem. 2022 12 22; 65(24):16338-16352.
PMID: 36449366

A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.
A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets. Nat Biotechnol. 2023 01; 41(1):128-139.
PMID: 36217030

SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1a/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells.
SARS-CoV-2 Diverges from Other Betacoronaviruses in Only Partially Activating the IRE1a/XBP1 Endoplasmic Reticulum Stress Pathway in Human Lung-Derived Cells. mBio. 2022 10 26; 13(5):e0241522.
PMID: 36125275

SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1a/XBP1 ER stress pathway in human lung-derived cells.
SARS-CoV-2 diverges from other betacoronaviruses in only partially activating the IRE1a/XBP1 ER stress pathway in human lung-derived cells. bioRxiv. 2022 Jun 13.
PMID: 35821981

A comprehensive SARS-CoV-2-human protein-protein interactome network identifies pathobiology and host-targeting therapies for COVID-19.
A comprehensive SARS-CoV-2-human protein-protein interactome network identifies pathobiology and host-targeting therapies for COVID-19. Res Sq. 2022 Jun 07.
PMID: 35677070

View All Publications

Investigator in the Pathogenesis of Infectious Disease Finalist
Burroughs Wellcome Fund
2011

Research Scholar
American Cancer Society
2010 - 2014

Career Development Award
NIH GLRCE
2008 - 2011

Career Development Award
Schweppe Foundation
2007 - 2009

Herman Lopata Hepatitis C Liver Scholar
American Liver Foundation
2007 - 2008

Outstanding New Investigator Award
NIH DDRCC
2006

Postdoctoral Fellow
American Cancer Society
2002 - 2005

National Research Service Award
NIH
1993 - 1995