Glenn C. Randall, PhD

Our laboratory investigates the roles of virus-host interactions in replication and pathogenesis. We study RNA viruses, including hepatitis C virus, dengue virus, Zika virus, and noroviruses. These are medically important viruses, causing cirrhosis/liver cancer, hemorrhagic fever, birth defects, and severe GI disease, respectively.



We have identified ~100 host cofactors of viral replication. We now study the importance of these cellular genes in diverse steps of the viral life cycle, including entry, the regulation of viral protein translation and RNA replication, modulation of cellular lipid metabolism, the establishment of viral replication complexes, the secretion of infectious virus, and control of infection by the innate immune system.

Rockefeller University
New York, NY
Postdoc - Virology
2005

The University of Chicago
Chicago, IL
Ph.D. - Virology
1999

University of Illinois
Urbana, IL
B.S. - Microbiology
1993

Nanotraps for the containment and clearance of SARS-CoV-2.
Chen M, Rosenberg J, Cai X, Hsuan Lee AC, Shi J, Nguyen M, Wignakumar T, Mirle V, Edobor AJ, Fung J, Donington JS, Shanmugarajah K, Lin Y, Chang E, Randall G, Penaloza-MacMaster P, Tian B, Madariaga ML, Huang J. Nanotraps for the containment and clearance of SARS-CoV-2. Matter. 2021 Jun 02; 4(6):2059-2082.
PMID: 33907732

Polymersomes decorated with SARS-CoV-2 spike protein receptor binding domain elicit robust humoral and cellular immunity.
Volpatti LR, Wallace RP, Cao S, Raczy MM, Wang R, Gray LT, Alpar AT, Briquez PS, Mitrousis N, Marchell TM, Sasso MS, Nguyen M, Mansurov A, Budina E, Solanki A, Watkins EA, Schnorenberg MR, Tremain AC, Reda JW, Nicolaescu V, Furlong K, Dvorkin S, Yu SS, Manicassamy B, LaBelle JL, Tirrell MV, Randall G, Kwissa M, Swartz MA, Hubbell JA. Polymersomes decorated with SARS-CoV-2 spike protein receptor binding domain elicit robust humoral and cellular immunity. bioRxiv. 2021 Apr 08.
PMID: 33851166

A novel soluble ACE2 protein totally protects from lethal disease caused by SARS-CoV-2 infection.
Hassler L, Wysocki J, Gelarden I, Tomatsidou A, Gula H, Nicoleascu V, Randall G, Henkin J, Yeldandi A, Batlle D. A novel soluble ACE2 protein totally protects from lethal disease caused by SARS-CoV-2 infection. bioRxiv. 2021 Mar 15.
PMID: 33758841

Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response.
Nguyen LC, Yang D, Nicolaescu V, Best TJ, Ohtsuki T, Chen SN, Friesen JB, Drayman N, Mohamed A, Dann C, Silva D, Gula H, Jones KA, Millis JM, Dickinson BC, Tay S, Oakes SA, Pauli GF, Meltzer DO, Randall G, Rosner MR. Cannabidiol Inhibits SARS-CoV-2 Replication and Promotes the Host Innate Immune Response. bioRxiv. 2021 Mar 10.
PMID: 33758843

Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2.
Kim Y, Wower J, Maltseva N, Chang C, Jedrzejczak R, Wilamowski M, Kang S, Nicolaescu V, Randall G, Michalska K, Joachimiak A. Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2. Commun Biol. 2021 02 09; 4(1):193.
PMID: 33564093

Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors.
Osipiuk J, Azizi SA, Dvorkin S, Endres M, Jedrzejczak R, Jones KA, Kang S, Kathayat RS, Kim Y, Lisnyak VG, Maki SL, Nicolaescu V, Taylor CA, Tesar C, Zhang YA, Zhou Z, Randall G, Michalska K, Snyder SA, Dickinson BC, Joachimiak A. Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors. Nat Commun. 2021 02 02; 12(1):743.
PMID: 33531496

A Novel Soluble ACE2 Variant with Prolonged Duration of Action Neutralizes SARS-CoV-2 Infection in Human Kidney Organoids.
Wysocki J, Ye M, Hassler L, Gupta AK, Wang Y, Nicoleascu V, Randall G, Wertheim JA, Batlle D. A Novel Soluble ACE2 Variant with Prolonged Duration of Action Neutralizes SARS-CoV-2 Infection in Human Kidney Organoids. J Am Soc Nephrol. 2021 Feb 01.
PMID: 33526471

Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus.
So CW, Randall G. Three-Dimensional Cell Culture Systems for Studying Hepatitis C Virus. Viruses. 2021 01 30; 13(2).
PMID: 33573191

Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice.
Brown RJP, Tegtmeyer B, Sheldon J, Khera T. Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice. Sci Adv. 2020 Nov; 6(45).
PMID: 33148654

Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro.
Drayman N, Jones KA, Azizi SA, Froggatt HM, Tan K, Maltseva NI, Chen S, Nicolaescu V, Dvorkin S, Furlong K, Kathayat RS, Firpo MR, Mastrodomenico V, Bruce EA, Schmidt MM, Jedrzejczak R, Muñoz-Alía MÁ, Schuster B, Nair V, Botten JW, Brooke CB, Baker SC, Mounce BC, Heaton NS, Dickinson BC, Jaochimiak A, Randall G, Tay S. Drug repurposing screen identifies masitinib as a 3CLpro inhibitor that blocks replication of SARS-CoV-2 in vitro. bioRxiv. 2020 Sep 01.
PMID: 32908976

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Investigator in the Pathogenesis of Infectious Disease Finalist
Burroughs Wellcome Fund
2011

Research Scholar
American Cancer Society
2010 - 2014

Career Development Award
NIH GLRCE
2008 - 2011

Career Development Award
Schweppe Foundation
2007 - 2009

Herman Lopata Hepatitis C Liver Scholar
American Liver Foundation
2007 - 2008

Outstanding New Investigator Award
NIH DDRCC
2006

Postdoctoral Fellow
American Cancer Society
2002 - 2005

National Research Service Award
NIH
1993 - 1995