R. conorii (red) and other spotted fever group rickettsial species express at least two outermembrane associated proteins that are sufficient to mediate “actin comet tail” (green) formation in infected cells.
R. conorii utilizes actin-based motility to spread intra- and intercellularly
Hematoxylin and eosin stained histopathology sections of mouse kidneys infected by Staphylococcus aureus. Staphylococcal abscess communities are surrounded by a massive influx of host immune cells.
Mouse kidneys show infection with Staphylococcus aureus
THP-1 macrophage infection with Legionella pneumophila. DNA stained with DAPI (blue), F-actin with Rhodamine-phalloidin (red) and Early Endosomes with EEA-1 (green). Taken from the lab of Howard Shuman. Shuman webpage
THP-1 macrophage infection with Legionella pneumophila
The HTRL is a Regional Biocontainment Laboratory, one of 13 located throughout the USA constructed by partnerships between the National Institute of Allergy and Infectious Diseases and local academic institutiions Learn more