Microbes exhibit variable forms of cellular metabolism, the distinctive properties of which reflect critical features of relevant microbial ecosystems. In the context of the gut microbiota, these metabolic processes generate numerous small molecules that influence host biology in a myriad of ways. Our research seeks to develop a fundamental understanding of the relationship between microbial metabolism and healthy/diseased states of the gut microbiota and, eventually, to exploit these insights in the development of targeted therapies.
University of California
Berkeley
Postdoctoral Fellow
2019
Northwestern University
Postdoctoral Associate
2016
Northwestern University
PhD
2013
Bard College
BA
2008
Versatile roles of protein flavinylation in bacterial extracyotosolic electron transfer.
Versatile roles of protein flavinylation in bacterial extracyotosolic electron transfer. bioRxiv. 2024 Mar 14.
PMID: 38559090
Dietary- and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration.
Dietary- and host-derived metabolites are used by diverse gut bacteria for anaerobic respiration. Nat Microbiol. 2024 Jan; 9(1):55-69.
PMID: 38177297
Bifidobacteria metabolize lactulose to optimize gut metabolites and prevent systemic infection in patients with liver disease.
Bifidobacteria metabolize lactulose to optimize gut metabolites and prevent systemic infection in patients with liver disease. Nat Microbiol. 2023 Nov; 8(11):2033-2049.
PMID: 37845315
Purine-ifying uric acid by gut microbes.
Purine-ifying uric acid by gut microbes. Cell Chem Biol. 2023 07 20; 30(7):706-708.
PMID: 37478828
Distinct Energy-Coupling Factor Transporter Subunits Enable Flavin Acquisition and Extracytosolic Trafficking for Extracellular Electron Transfer in Listeria monocytogenes.
Distinct Energy-Coupling Factor Transporter Subunits Enable Flavin Acquisition and Extracytosolic Trafficking for Extracellular Electron Transfer in Listeria monocytogenes. mBio. 2023 02 28; 14(1):e0308522.
PMID: 36744898
Listeria monocytogenes two component system PieRS regulates secretion chaperones PrsA1 and PrsA2 and enhances bacterial translocation across the intestine.
Listeria monocytogenes two component system PieRS regulates secretion chaperones PrsA1 and PrsA2 and enhances bacterial translocation across the intestine. Mol Microbiol. 2022 09; 118(3):278-293.
PMID: 35943959
Solution structure and dynamics of the mitochondrial-targeted GTPase-activating protein (GAP) VopE by an integrated NMR/SAXS approach.
Solution structure and dynamics of the mitochondrial-targeted GTPase-activating protein (GAP) VopE by an integrated NMR/SAXS approach. Protein Sci. 2022 05; 31(5):e4282.
PMID: 35137487
Stickland metabolism in the gut.
Stickland metabolism in the gut. Nat Microbiol. 2022 05; 7(5):603-604.
PMID: 35505246
Listeria monocytogenes requires cellular respiration for NAD+ regeneration and pathogenesis.
Listeria monocytogenes requires cellular respiration for NAD+ regeneration and pathogenesis. Elife. 2022 04 05; 11.
PMID: 35380108
RibU is an essential determinant of Listeria pathogenesis that mediates acquisition of FMN and FAD during intracellular growth.
RibU is an essential determinant of Listeria pathogenesis that mediates acquisition of FMN and FAD during intracellular growth. Proc Natl Acad Sci U S A. 2022 03 29; 119(13):e2122173119.
PMID: 35316134